Get Antihypertensive Agents PDF

By Edward L. Engelhardt (Eds.)

ISBN-10: 0841202680

ISBN-13: 9780841202689

ISBN-10: 0841203334

ISBN-13: 9780841203334

content material: [Beta]-adrenoceptor antagonists as antihypertensive brokers / Richard Clarkson --
Centrally performing antihypertensive brokers / Wolfgang Hoefke --
Antihypertensives appearing by way of a peripheral mechanism / John E. Francis --
Antihypertensive brokers as noticeable through the clinician / Gaddo Onesti.

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P. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1976. Cl N St 608 Figure 14. Effects of a group of clonidine derivatives on blood pressure in spinal rats and on heart rate in vagotomized rats. 4. -5,25 -4,50 -3,75 -3,0 -2,25 -1,50 -0,75 0 0,75 1,50 ln(»c-adrenoceptor activity"distribution quotient) blood pressure increase in spinalised rats Arzneimittelforschung Figure 15. Relationship between peripheral α-adrenoceptor activity, lipoid solubility, and centrally mediated cardiodepressor activity.

Med. , (1974), 50, 253. 28. , Am. J . , (1973), 32, 575. 29. , And Walter, I . , Am. Heart J . , (1972), 83, 589. 30. , F o l i a med. , (1971), 14, 67-71. 31. 32. 33. 34. 35. 36. , Am. J . , (1972), 29, 633. , Am. J . , (1973), 32, 511; see also New Engl. J . , (1972), 287, 1209. , New Engl. J . , (1972), 286, 441. , B r i t . Med. J . (1974), 1. 60. , Lewis. , J . Pharm. Explt. , (1974), 188, 394. , Clin. Explt. Pharmacol. , (1974), 1, 333. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1976.

ACS Symposium Series; American Chemical Society: Washington, DC, 1976. ANTIHYPERTENSIVE AGENTS CHEMICAL STRUCTURE HO CH 2 NH 2 CH 3 H O - ^ ^ - C H - Ç - COOH 2 CH ~^3 CH _CH 2~ - 70 30 0 0 300 0 200 0 30 0 0 30 0 0 3 c- NH ChI HO CH 2 00 N H 3 HO HO decrease in blood pressure mmHg 3 H O - ^ ^ - C H - C - COOH HO dose mg/kg '• Ρ 0 0 H 2 CH 3 C 3 H O - ^ ^ - C H - C - COOH 2 NH H CO 2 CH 3 3 HO-^^-CH —Ç—COOH 2 HO NH 2 CH 3 H O - ^ ^ - C H - C — COOH 2 NH-CH3 Figure 28. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1976.

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Antihypertensive Agents by Edward L. Engelhardt (Eds.)


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