By Judah Folkman (auth.), William D. Figg, Judah Folkman (eds.)
Dr. Judah Folkman, “father of angiogenesis”, (1933-2008) used to be the Director of the Vascular Biology software, Andrus Professor of Pediatric surgical procedure, and Professor of phone Biology at Harvard University's Boston kid's medical institution. within the 1971 factor of the recent England magazine of medication, he proposed the speculation that tumor progress is angiogenesis based. This premise used to be the root of this box of study and has develop into the point of interest of scientists around the world. due to Folkman's discovery and examine, the probabilities of antiangiogenic and angiogenic remedy have broadened past melanoma to many noncancerous diseases.
This publication represents the 1st assortment in a quantity of which Dr. Folkman is co-editor. Dr. Folkman authored approximately four hundred unique papers and greater than a hundred e-book chapters.
Dr. William Figg is the manager of the Molecular and medical Pharmacology application on the nationwide melanoma Institute, nationwide Institutes of well-being. over the last 15 years, his laboratory and sanatorium on the NCI have excited by the improvement of angiogenesis inhibitors. Dr. Figg has released greater than 380 publications.
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Extra info for Angiogenesis: An Integrative Approach From Science to Medicine
111. Dorrell MI, Aguilar E, Scheppke L, Barnett FH, Friedlander M. Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. Proc Natl Acad Sci U S A 2007; 104:967. 112. Jain RK, Tong RT, Munn LL. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res 2007; 67:2729. 113. Fukumura D, Jain RK. Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization.
Nature 2006; 442:453–456. 66. Bayliss PE, Bellavance KL, Whithead GG, Abrams JM, Aegerter S, Robbins HS, Cowan DB, Keating MT, O’Reilly T, Wood JM, Roberts TM, Chan J. Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nat Chem Biol 2006; 2(5):265–273. 67. Auerbach R, Kubai L, Knighton D, Folkman J. A simple procedure for the long-term cultivation of chicken embryo. Dev Biol 1974; 41:391. 68. Ausprunk DH, Knighton DR, Folkman J. Differentiation of vascular endothelium in the chick chorioallantois: a structural and autoradiographic study.
This chapter reviews the evolution of approaches we have developed or adapted to obtain a better understanding of changes in three-dimensional vascular architecture, vascular phenotype and hierarchy, and the cell biology of endothelial cells and pericytes in vivo. The strategy was first to understand the properties of a relatively simple vascular network under baseline conditions and then to determine how the vasculature changed under pathological conditions. Models in mice or rats were used to compare angiogenesis and vascular remodeling in chronic inflammation and cancer.
Angiogenesis: An Integrative Approach From Science to Medicine by Judah Folkman (auth.), William D. Figg, Judah Folkman (eds.)