By Jeffrey M. Drazen (auth.), Zeliha Yazici, Giancarlo C. Folco, Jeffrey M. Drazen, Santosh Nigam, Takao Shimizu (eds.)
This quantity, the lawsuits of the twelfth overseas convention on Advances in Prostaglandin, Leukotriene and different Bioactive Lipid examine: uncomplicated technological know-how and scientific functions, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid examine with detailed cognizance to melanoma, cardiovascular ailments, gastrointestinal ailments and breathing illnesses. particular themes coated contain the position of leukotrienes and lipoxins in irritation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.
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Extra info for Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research: Basic Science and Clinical Applications
The results of this study showed that IL-4 induced expression of l5-LO in human monocytes is accompanied by a significant inhibition of LTB4 production upon challenge with either the Ca++-ionophore A23l87 or a physiologically relevant stimulus such as opsonized zymosan. The potential for IL-4 to significantly change the profile of arachidonic acid metabolites from the production of leukotrienes to thatof l5(S)-HETE raises important questions on the biological relevance of such an effect. Recently we have shown that l5(S)-HETE is present in high concentration in induced sputum obtained from chronic bronchitis patients, and that its concentration inversely correlate both with the percentage of neutrophils recovered and the concentration of LTB4 in induced sputum .
Am J Respir Crit Care Med 2002; 165:861-866. Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chin chilli VM, Cooper DM, Fahy N, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Marrin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. The effect of polymorphisms of the beta(2)adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med 2000; 162:75-80. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing.
Profita M et al. Interleukin-4 Enhances 15-Lipoxygenase Activity and Incorporation of 15(S)-HETE into Cellular Phospholipids in Cultured Pulmonary Epithelial Cells. Am J Respir Cell Mol BioI, 1999; 20(1): 61-68. Levy BD et aI. Lipid mediator class switching during acute inflammation: signals in resolution . Nature Immuno12001 ; 2(7): 612-618. Chapter #5 LIPOXINS AND ASPIRIN-TRIGGERED AIRWAY RESPONSES LIPOXINS IN Bruce D. Levy, George T. De Sanctis, Pallavi R. Devchand, Eugene Kim, Kate Ackerman, Birgitta Schmidt, Wojciech Szczeklik, Jeffrey M.
Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research: Basic Science and Clinical Applications by Jeffrey M. Drazen (auth.), Zeliha Yazici, Giancarlo C. Folco, Jeffrey M. Drazen, Santosh Nigam, Takao Shimizu (eds.)