By L. Sprague De Camp
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Extra info for A Gun for Dinosaur
111. Dorrell MI, Aguilar E, Scheppke L, Barnett FH, Friedlander M. Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. Proc Natl Acad Sci U S A 2007; 104:967. 112. Jain RK, Tong RT, Munn LL. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res 2007; 67:2729. 113. Fukumura D, Jain RK. Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization.
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This chapter reviews the evolution of approaches we have developed or adapted to obtain a better understanding of changes in three-dimensional vascular architecture, vascular phenotype and hierarchy, and the cell biology of endothelial cells and pericytes in vivo. The strategy was first to understand the properties of a relatively simple vascular network under baseline conditions and then to determine how the vasculature changed under pathological conditions. Models in mice or rats were used to compare angiogenesis and vascular remodeling in chronic inflammation and cancer.
A Gun for Dinosaur by L. Sprague De Camp